Abstract Periodontal regeneration faces multiple challenges, the most important being cellular insufficiency. In an attempt to improve defect cellularity, we aimed to demonstrate enhancing cellular attraction using arginine-glycine-aspartic acid (RGD) adhesion molecule legend blended hydrogel within the intrabony defects. Methodology Forty-five intrabony defects were selected from patients with stage III or IV - grade A or B periodontitis and divided randomly into three equal groups of 15 each: group1 (G1): received minimally invasive surgical technique (MIST) alone, group2 (G2): received MIST and placebo hydrogel injection, and group3 (G3): were treated with MIST and RGD hydrogel injection. Primary outcomes 6 months following therapy were; defect base fill (DBF) and defect width measurement (DW); secondary outcomes were clinical attachment level (CAL), pocket depth (PD), plaque index (PI), gingival index (GI), and biochemical analysis of bone morphogenetic protein (BMP-2) evaluated at 1,7,14 and 21 days following therapy. Results Significant improvements in DBF, CAL, and PD were observed in the three studied groups 6 months following therapy compared to baseline (p<0.05). A significant improvement in DBF was reported in G3 compared to G1 and 2 (p=0.005). Additionally, a significantly higher CAL gain was reported in G3 compared to that of G1 (p=0.02). Group 3 was associated with a significantly higher level of BMP-2 compared to G1 and G2 in all reported periods. Conclusion RGD peptide carried on a hydrogel delivery agent and contained with a minimally invasive flap could be a reliable option in improving the outcomes of periodontal therapy.

Abstract The wheat variety NIA-Shaheen (CIM-04-10) has high grain yield and modern plant architecture. It has wide adaptability, increased tiller production, bold grains, high starch and protein content, and good tolerance to disease and environmental stresses, particularly water stress. NIA-Shaheen has high yield potential (7184 kg ha-1).

RESUMO Tem se passado 15 anos desde que o anticorpo monoclonal trastuzumab, direcionado contra a proteina HER2, foi introduzido na clinica e revolucionou o tratamento de pacientes com câncer de mama HER2-positivo. Apesar disto, a maioria das pacientes com câncer de mama metastático e HER2-positivo ainda mostram progressão da doença, destacando a necessidade de desenvolver novas terapias. O interesse contínuo em novas moléculas alvo levou ao desenvolvimento do pertuzumab, o primeiro agente de uma nova classe, os inibidores da dimerização de HER. Pertuzumab é um novo anticorpo humanizado recombinante dirigido contra o domínio II extracelular da proteína HER2 que é necessário para a heterodimerização de HER2 com outros receptores HER, o que conduz à ativação de vias de sinalização intracelular. O pertuzumab combinado com trastuzumab e docetaxel foi aprovado como terapia de primeira linha para pacientes com câncer de mama metastático HER2-positivo e é atualmente indicado como padrão de tratamento para estas pacientes. Como terapia neoadjuvante, o medicamento recebeu aprovação do FDA em 2013. Além disso, o pertuzumab também está sendo avaliado como terapia adjuvante. O potencial do pertuzumab se baseia no bloqueio completo do eixo HER2/3 quando administrado em associação com o trastuzumab. Este artigo sintetiza dados pré-clínicos e clínicos do pertuzumab e destaca os mecanismos de ação complementares que explicam a atividade sinérgica da combinação pertuzumab-trastuzumab.

ABSTRACT It has now been 15 years since the HER2-targeted monoclonal antibody trastuzumab was introduced in clinical and revolutionized the treatment of HER2-positive breast cancer patients. Despite this achievement, most patients with HER2-positive metastatic breast cancer still show progression of their disease, highlighting the need for new therapies. The continuous interest in novel targeted agents led to the development of pertuzumab, the first in a new class of agents, the HER dimerization inhibitors. Pertuzumab is a novel recombinant humanized antibody directed against extracellular domain II of HER2 protein that is required for the heterodimerization of HER2 with other HER receptors, leading to the activation of downstream signalling pathways. Pertuzumab combined with trastuzumab plus docetaxel was approved for the first-line treatment of patients with HER2-positive metastatic breast cancer and is currently used as a standard of care in this indication. In the neoadjuvant setting, the drug was granted FDA-accelerated approval in 2013. Pertuzumab is also being evaluated in the adjuvant setting. The potential of pertuzumab relies in the dual complete blockade of the HER2/3 axis when administered with trastuzumab. This paper synthetises preclinical and clinical data on pertuzumab and highlights the mechanisms underlying the synergistic activity of the combination pertuzumab-trastuzumab which are essentially due to their complementary mode of action.

Este estudio presenta una exploración aeromagnética para delimitar la estructura subsuperficial y el marco tectónico del distrito de Fayoum-Cairo, que sufrió un terremoto el 12 de octubre de 1992 de magnitud M=5.7. Los análisis de datos sismicidad y aeromagnéticos señalan tres fallas tectónicas significativas con tendencias NE-SO, NO-SE y E-O. El subsuelo se elevó en el norte y en el centro a una profundidad de 1,3 kilómetros, y se hundió en el sur con una profundidad de 2,5 kilómetros. Esta es una zona sísmicamente activa que en su historia ha tenido terremotos dañinos. En 1847 tuvo lugar un terremoto con intensidad epicentral máxima (escala sismológica de Mercalli) de VII. En el lado este se estudiaron las fuentes de terremotos en diferentes partes. Estas fuentes crearon eventos de magnitud moderada M<5. Los mecanismos focales de los eventos principales en estas fuentes son generalmente fallas de desgarre con componente normal. El mecanismo focal del terremoto del 12 de octubre de 1992 es una falla tipo normal con fuertes movimientos NO-SE. Las soluciones de estas fallas son consistentes con las tendencias tectónicas de los datos aeromagnéticos antes mencionados y sugieren que la nueva tectónica del noreste de África es predominante.

An aeromagnetic reconnaissance study is presented to delineate the subsurface structure and tectonic setting at the Fayoum-Cairo district, which experienced a damaging earthquake on October 12, 1992 of magnitude (M = 5.7). Analysis of aeromagnetic and seismicity data demonstrate three significant tectonic faults with trending to the NE-SW, NW-SE and E-W. The basement is uplifted in the northern and central parts with a depth of 1.3 km, and deepening in the southern part with a depth of 2.5 km. This is a seismically active zone and historically has experienced damaging earthquakes. In 1847, a damaging earthquake with maximum epicentral intensity (Modified Mercalli Intensity (MMI) = VII) was located there. On the eastern side, earthquake sources are well recognized at different locations. These sources created events of moderate size magnitude M < 5. The focal mechanisms of the major events from these sources are generally strike-slip with normal component. The focal mechanism of the earthquake on October 12, 1992 is normal fault type with strike trends in the NW-SE direction. These fault plane solutions are consistent with the tectonic trends derived from the aeromagnetic data mentioned above and suggest that the new tectonics of northeast Africa is predominant.

En el presente trabajo, aplicamos la Técnica de Fuente Electromagnética Controlada (CSEM) para obtenerla imagen del centro dinámico de la migración de las fracturas, fisuras y grietas de la superficie somera en una nueva área de vivienda en la ciudad de 15 de mayo cerca a El Cairo. Esta zona constituye el centro de la debilidad del subsuelo, que a su vez, interactúacon el centro de peso de la construcción que ha llevado a colapsos catastróficos. La técnica de Control de Fuente electromagnética se ha desarrollado recientemente para monitorearla migración del centro de la debilidad, representados por la acumulación de fisuras y grietas de la superficie somera. Tres perfiles compuestos se han recogido en 2008. Este estudio se ha seguido realizando con dos perfiles en 2010. Uno de estos perfiles se ha repetido para observar los cambios, y el segundo perfil se ha medido entre los otros dos perfiles de 2008. El último perfil se ha realizado para estudiar la relación mutua entre las mediciones de los dos ciclos. Los objetivos de todo el proceso es validar la eficacia de la técnica para recoger los mínimos cambios del centro de la debilidad, y así, estudiar su relación con el centro de peso de construcciones cercanas, para recomendar un procedimiento que reduzca al mínimo la destrucción de los recursosen el sitio de la investigación. Los datos medidos se haninterpretado y representado en gráficos que muestran la distribución de la heterogeneidad de los parámetros geo-eléctricos en el subsuelo; además, en una serie de seccionescruzadas geoeléctrica se representa las frecuenciasutilizadasdurante el estudio. El estudio concluye que (1) el centro de la zona agrietada se mueve hacia arriba cerca de la superficie de la tierra, (2) el contenido de agua está bajando, produciendola sequedad del suelo apoca profundidad, y (3) el sitio se volviómás estable en 2010 que en 2008, sin embargo, los producto de la destrucción siguen susceptiblesa colapsos.Además, la situación refleja la relación entre el contenido de agua y los cambios en el centro de debilidad.

In the present work, we involve the Control Source Electromagnetic (CSEM) Technique to image the dynamic migration center of the near surface fractures, fissures, and cracks in anew dwelling area at 15th of May city close to Cairo. This area forms the center of the zonal weakness of the subsoil, which in turn, interact with the weight center of the construction leading to catastrophic collapses. The control source electromagnetic technique has been developed recently to monitor the migration of the weakness center represented as the accumulative fissures and cracks in the near surface. Three composite profiles of wide and planshet mesh data have been collected in 2008. This survey has been followed by performing two profiles in 2010; one ofthese profiles has been repeated to observe the situation changes, and the second profile has been measured between the other two profiles of 2008. The last profile had been performed to study the mutual relation between the measurements of the two cycles. The objectives of the whole process are to validate the capability of the technique to pick the minor changes of the weakness center, consequently, study its relation to the weight center of the adjacent construction to produce a recommended procedure to minimize the destruction resources at the site of investigation. The measured data has been interpreted and represented in graphs showing the distribution of the heterogeneity of the geoelectric parameters in the subsoil, furthermore, in a series of geoelectric cross section representing the applied frequencies used during the survey. The study concludes that (1) the center of the cracked zone is moving upward closer to the surface of the ground and heaver, (2) the water content is moving downward producing soil dryness at the shallow depths, and (3) the site became more stable in 2010 than 2008, however, the destruction resources remain warning with collapse events. Furthermore, the situation reflects the relation between the water content and the changes in the weakness center.